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Trends Microbiol. 1994 Jan;2(1):20-4.

Capturing host plasmin(ogen): a common mechanism for invasive pathogens?

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Dept of Medicine, University of Florida College of Medicine, Gainesville 32610-0277.


Plasmin is a potent enzyme that can dissolve blood clots and degrade extracellular matrix proteins. A number of pathogenic bacteria produce plasminogen activators. Many of these organisms can also bind plasmin(ogen) to surface receptors and protect the active enzyme from physiological inhibition. Cell-surface localization of plasmin may be a common mechanism used by bacteria to facilitate movement through normal tissue barriers.

[Indexed for MEDLINE]

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