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Biochim Biophys Acta. 1994 Apr 13;1205(2):262-7.

Influence of bulky side chains of amino acids on the solution conformation of peptide fragment (81-92) derivatives of CD4, TYICEVEDQKEE, as studied by NMR spectroscopy and molecular modeling.

Author information

1
Institute of Chemistry, Academia Sinica, Taipei, Taiwan, R.O.C.

Abstract

Solution conformation of CD4 fragment 81-92 TYICEVEDQKEE and two of its benzylated analogues was determined by two-dimensional 1H NMR spectroscopy, distance geometry and simulated annealing techniques. The structures of both benzylated derivatives are similar but are distinct from that of wild-type dodecapeptide. It is concluded from structural analysis that bulky side chain(s) of amino acid(s) at an appropriate position can have a marked effect on the conformation and thus the functions of a peptide.

PMID:
8155707
DOI:
10.1016/0167-4838(94)90243-7
[Indexed for MEDLINE]

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