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Ann Rheum Dis. 1994 Mar;53(3):163-6.

Bone turnover in non-steroid treated rheumatoid arthritis.

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  • 1Department of Rheumatology, University Hospital of Wales, Cardiff, United Kingdom.

Abstract

OBJECTIVE:

To examine whether changes in cancellous bone turnover and resorption cavity depth contribute to bone loss in patients with non-steroid treated rheumatoid arthritis.

METHODS:

Iliac crest biopsies were obtained from 37 patients with non-steroid treated rheumatoid arthritis, 13 male and 24 female, aged 37-71 years. Bone turnover and resorption cavity characteristics were quantitatively assessed using semiautomated computerised techniques.

RESULTS:

When compared with age- and sex-matched control values, there was a significant reduction in bone formation rate at tissue level and activation frequency (P < 0.001) in the patient group. The eroded perimeter, mean and maximum eroded depth and cavity area were also significantly reduced (P < 0.01, < 0.005, < 0.01 and < 0.005 respectively).

CONCLUSION:

These results demonstrate low bone turnover in non-steroid treated rheumatoid arthritis and indicate that the reduced bone mass in these patients is due mainly to a negative remodelling balance.

PMID:
8154932
PMCID:
PMC1005279
[PubMed - indexed for MEDLINE]
Free PMC Article
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