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Parasitol Res. 1994;80(1):87-8.

The influence of thyroxine and propyl thiouracil on Parastrongylus malaysiensis infection in rats.

Author information

1
Jabatan Zoologi, Universiti Kebangsaan Malaysia, Bangi.

Abstract

Daily intramuscular injection with thyroxine (T4) at a dose of 2.5 micrograms/100 g body weight decreased the larvae and adult worm burden of Parastrongylus malaysiensis in the brain and pulmonary arteries of male Sprague-Dawley albino rats. In contrast, rats treated with propyl thiouracil (PTU), an antithyroid drug, at a dose of 3.75 mg/100 g body weight retained greater numbers of larvae and adult worms. The results may reflect the contrasting immunomodulatory effects of T4 and PTU that influence the susceptibility of the host.

PMID:
8153134
DOI:
10.1007/bf00932632
[Indexed for MEDLINE]

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