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Neurosci Lett. 1993 Dec 24;164(1-2):233-5.

Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease.

Author information

1
Division of Neuropathology, Tokyo Institute of Psychiatry, Japan.

Abstract

Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.

PMID:
8152607
DOI:
10.1016/0304-3940(93)90899-v
[Indexed for MEDLINE]

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