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Nature. 1994 Apr 21;368(6473):703-10.

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.

Author information

1
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

Abstract

The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.

PMID:
8152482
DOI:
10.1038/368703a0
[Indexed for MEDLINE]

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