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Leukemia. 1994 Apr;8(4):560-3.

The t(14;18) in a patient with de novo acute lymphoblastic leukemia is associated with t(8;9).

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ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, UK.


Cytogenetic analysis of a bone marrow aspirate from a patient with acute lymphoblastic leukemia (ALL) revealed the presence of a complex karyotype containing the translocation, t(14;18)(q32;q21). Further investigations using fluorescence in situ hybridization (FISH) allowed the characterization of an additional translocation, t(8;9)(q24;p1?). The association of t(14;18)(q32;q21) and t(8;9)(q24;p13) has recently been described in two patients with de novo ALL (Nacheva et al. Blood 1993;82:231-240) and this report supports these findings.

[Indexed for MEDLINE]

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