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Eur J Immunol. 1994 Apr;24(4):980-4.

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells.

Author information

1
Wellcome Laboratory for Experimental Parasitology, University of Glasgow.

Abstract

The balance between T helper type 1 (Th 1) and T helper type 2 (Th2) cells determines the outcome of many important diseases. Using cloned murine T cell lines, evidence is provided that Th1, but not Th2, cells can be activated by specific antigens or a T cell mitogen, concanavalin A, to produce large amounts of nitric oxide (NO). Furthermore, NO can inhibit the secretion of interleukin (IL)-2 and interferon-gamma by Th1 cells but has no effect on IL-4 production by Th2 cells. Th1 and Th2 cells can, thus, be distinguished by their differential production of and susceptibility to NO. NO exerts a self-regulatory effect on Th1 cells which are implicated in immunopathology.

PMID:
8149966
DOI:
10.1002/eji.1830240430
[Indexed for MEDLINE]

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