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Brain Res Dev Brain Res. 1993 Dec 17;76(2):268-71.

Gelsolin is localized in neuronal growth cones.

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1
Department of Neurochemistry and Neuropharmacology, Osaka University Medical School, Japan.

Abstract

Gelsolin, a Ca(2+)-sensitive actin filament-severing protein, is involved in actin turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is localized in both filopodia and the body part of growth cones of differentiated PC12 cells with nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified gelsolin as one of the molecular bases for the Ca(2+)-dependent movement of growth cones.

PMID:
8149595
[Indexed for MEDLINE]
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