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Biochim Biophys Acta. 1994 Apr 6;1217(3):317-21.

Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.

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Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.


We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart.

[Indexed for MEDLINE]

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