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FEBS Lett. 1994 Mar 28;342(1):38-42.

Tyrosine-194 of glycogenin undergoes autocatalytic glucosylation but is not essential for catalytic function and activity.

Author information

1
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101.

Abstract

Glycogenin is the protein primer for glycogen synthesis. By autocatalytic transglucosylation from UDPglucose, it creates a malto-octaose chain attached to its Tyr-194. It has been uncertain whether the autocatalysis includes the addition of the first glucose residue to Tyr-194. We now show this to be the case. However, we also demonstrate, contrary to a claim by others, that Tyr-194 is not necessary for the catalytic function and activity of glycogenin.

PMID:
8143846
DOI:
10.1016/0014-5793(94)80580-6
[Indexed for MEDLINE]
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