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Exp Cell Res. 1994 Apr;211(2):314-21.

Induction of a common pathway of apoptosis by staurosporine.

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Centre de Recherche Louis-Charles Simard, Institut du Cancer de Montréal, Québec, Canada.


The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA fragmentation typical of apoptosis. This occurred in a number of cell lines from various origins regardless of the state of differentiation and cell cycle phase, suggesting the presence of a common inducible suicide pathway. The broad apoptotic activity of staurosporine appears to be unique among other protein kinase or phosphatase inhibitors we tested. Results obtained in a cell-free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in a ubiquitous signal for the induction of DNA fragmentation and apoptosis.

[Indexed for MEDLINE]

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