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Bioessays. 1993 Dec;15(12):799-805.

The secretion pathway of IgA protease-type proteins in gram-negative bacteria.

Author information

1
Max-Planck-Institut für Biologie, Abteilung Infektionsbiologie, Tübingen, Germany.

Abstract

The pathogenic, Gram-negative bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae, secrete immunoglobulin A1 proteases into their extracellular surroundings. An extraordinary feature in the secretory pathway of these putative virulence factors is a self-directed outer membrane transport step allowing the proteins to be secreted autonomously, even from foreign Gram-negative host cells like Escherichia coli. Here we summarize recent achievements in the understanding of IgA protease outer membrane translocation.

PMID:
8141798
DOI:
10.1002/bies.950151205
[Indexed for MEDLINE]

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