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Antiviral Res. 1994 Jan;23(1):63-76.

Studies on mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro.

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  • 1Unité de Biologie Moléculaire, Centre de Recherches du Service de Santé des Armées, La Tronche, France.


Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [3H]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.

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