Send to

Choose Destination
Am J Med Sci. 1994 Feb;307 Suppl 1:S75-80.

The relationship of sodium sensitivity to insulin resistance.

Author information

Department of Pediatrics, University of Minnesota, Minneapolis.


Substantial epidemiologic evidence has indirectly implicated sodium intake in the pathogenesis of hypertension. The concept of sodium-sensitivity as a cause of essential hypertension has been addressed by many investigators, yet the pathogenesis of this salt-sensitivity remains unclear. Although not well appreciated, most studies have shown that regardless of sodium intake or the presence or absence of hypertension, sodium-sensitive subjects tend to weigh more than sodium-resistant subjects. Insulin-resistance has been postulated to be responsible for enhanced sodium retention in obese individuals; therefore, insulin-resistance may be critical to the pathogenesis of sodium-sensitivity in individuals with essential hypertension. This article summarizes the data relating insulin and or insulin-resistance to sodium sensitivity in obesity, diabetes, and in non-obese subjects with essential hypertension.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center