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Trends Biochem Sci. 1994 Jan;19(1):15-8.

Convergent evolution: the need to be explicit.

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Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0634.


Convergence as a phenomenon in molecular evolution is an issue that confuses many discussions. Often the problem is that not enough care is taken to state exactly what kind of convergence one has in mind. Functional and mechanistic convergence are both common, and some structural convergence has probably occurred, but a convincing case for genuine sequence convergence has yet to be made.

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