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FEBS Lett. 1994 Mar 14;341(1):1-4.

Cytochrome oxidase evolved by tinkering with denitrification enzymes.

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1
European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

The cytochrome bc complex which is encoded by the fixNOPQ operon in Bradyrhizobium japonicum, is the most distant member of the haem-copper cytochrome oxidase family. We have found that its major subunit, FixN, is homologous to the NorB subunit of nitric oxide reductase in a purple bacterium. A second evolutionary link between cytochrome oxidases and denitrification enzymes is the presence of a similar binuclear copper site in cytochrome aa3 (the mitochondrial oxidase) and nitrous oxide reductase. This centre was probably acquired by a primitive FixN-type oxidase, leading to the evolution of the mitochondrial-type oxidase. These links suggest that the oxygen-reducing respiratory chain developed from the anaerobic, denitrifying respiratory system.

PMID:
8137905
DOI:
10.1016/0014-5793(94)80228-9
[Indexed for MEDLINE]
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