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Brain Res. 1994 Jan 7;633(1-2):21-6.

Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula.

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Department of Psychology, University of Illinois at Chicago 60680.


In rats treated systemically with either amphetamine, amfonelic acid or apomorphine, large numbers of cells displaying Fos-like immunoreactivity (FLI) could be seen in the lateral zone of the lateral habenula. The induction of FLI by amphetamine could be blocked either by pretreatment with haloperidol or by 6-hydroxydopamine lesions of ascending dopamine fibers at the level of the lateral hypothalamus. In contrast, a variety of stressors selectively induced FLI in the most medial portion of the lateral habenula. These findings support the concept of a functional differentiation of the medial and lateral regions of the lateral habenula and provide further evidence for involvement of the habenula in the circuitry of the basal ganglia.

[Indexed for MEDLINE]

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