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Trends Microbiol. 1993 Sep;1(6):232-5.

On the mechanism of action of quinolone drugs.

Author information

1
Dept of Pharmaceutical Sciences, University of Padova, Italy.

Abstract

Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.

PMID:
8137121
[Indexed for MEDLINE]

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