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Biochem Biophys Res Commun. 1994 Mar 15;199(2):582-6.

Modulation of 12-0-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by calcium and verapamil in mouse.

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College of Pharmacy, South Dakota State University, Brookings 57007-0099.


Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA). In the present study, the effects of dietary calcium supplement and calcium and verapamil injections on TPA-induced ODC activity in skin was investigated in CD-1 and SENCAR mouse. Dietary calcium supplement did not influence ODC induction caused by TPA. However, calcium injections enhanced the TPA-induced ODC activity in CD-1 and SENCAR mouse skin. Verapamil injections resulted in a significant decrease in TPA-induced ODC activity in CD-1 and SENCAR mice. These results suggest that calcium and calcium antagonists may play a role in skin tumor promotion caused by TPA.

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