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Radiology. 1994 Apr;191(1):41-51.

Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings.

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1
Department of Radiology, Massachusetts General Hospital, Charlestown 02129.

Abstract

PURPOSE:

To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas.

MATERIALS AND METHODS:

CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material.

RESULTS:

The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity.

CONCLUSION:

MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

[Indexed for MEDLINE]

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