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J Oral Maxillofac Surg. 1994 Apr;52(4):397-400; discussion 400-1.

Cefadroxil concentrations in human serum, gingiva, and mandibular bone following a single oral administration.

Author information

1
Nihon University School of Dentistry at Matsudo, Japan.

Abstract

Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral dose. The mean peak concentrations in serum, gingiva, and mandibular bone occurred at the identical time, 3 hours, and were 12.92 micrograms/mL, 6.50 micrograms/g, and 2.67 micrograms/g, respectively. Mean cefadroxil concentration ratios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandibular bone at the peak time exceeded the minimum inhibitory concentrations for 90% of clinically isolated strains of a alpha-hemolytic streptococci.

PMID:
8133373
DOI:
10.1016/0278-2391(94)90447-2
[Indexed for MEDLINE]

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