Format

Send to

Choose Destination
Brain Res. 1993 Dec 24;631(2):349-51.

Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization.

Author information

1
Faculty of Medicine, Memorial University, St. John's, Nfld, Canada.

Abstract

The effect of myo-inositol was examined on 5-HT2 receptor mediated facilitation of NMDA depolarization of rat neocortical neurons in vitro. Myo-inositol (1-10 mM) potentiated the 5-HT facilitation, the potentiation increasing linearly with log 5-HT concentration. Myo-inositol also eliminated 5-HT induced heterologous desensitization of muscarinic and alpha 1-adrenergic receptor mediated facilitation. Our findings suggest that 5-HT induced homologous and heterologous desensitization results in part from depleting phosphoinositide substrate.

PMID:
8131066
DOI:
10.1016/0006-8993(93)91557-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center