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Arch Mal Coeur Vaiss. 1993 Aug;86(8):1187-91.

[Evaluation of the aging change in cardiac autonomic nervous system by automated clinical measurement].

[Article in French]

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Service de médecine interne et cardiologie, CHU de Grenoble.


The object of this study was to establish normal values for age of clinical tests of autonomic nervous system activity based on an automatic measuring system. Ninety-seven subjects (50 M/47 F) aged 20 to 85 years (average 45 +/- 13 years) with a normal clinical examination and no medication were included in the study. The blood pressure (BP) and heart rate (HR) were measured continuously with the Finapres system. After a resting period, the BP and HR were measured continuously in 5 different situations: dorsal decubitus position for 7 minutes; on getting up actively in less than 3 seconds and for 9 minutes in the upright positions, during deep breathing at 6c/min and Valsalva manoeuvre during a handgrip test at 30% of maximal voluntary strength for 3 minutes. A specific programme (ISN-CNRS) initiated the calculations of the test and performed direct and crossed spectral analysis in the lying and standing positions. The average BP was 120 +/- 18/66 +/- 11 mmHg and HR was 67 +/- 9 b/min. A negative linear correlation was observed with age with respect to the 3 tests investigating vagal activity: 30/15 ratio, spontaneous variations of respiration and HR, ratio of HR at the end of Valsalva with r = -0.43, r = -0.60, r = -0.34 (p < 0.001). The other two tests: variation of systolic BP 1 min 30 after standing and variation of diastolic BP during the handgrip did not change with age.(ABSTRACT TRUNCATED AT 250 WORDS).

[Indexed for MEDLINE]

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