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Cell. 1994 Feb 25;76(4):747-60.

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.

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D├ępartement des Biotechnologies, Institut Pasteur, Paris, France.


As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in G0/G1 while c-Jun overexpression produces larger S/G2 and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two closely related transcription factors can function in an opposing manner.

[Indexed for MEDLINE]

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