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BMJ. 1994 Feb 12;308(6926):441-3.

Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Côte d'Ivoire.

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1
Projet RETRO-CI, Abidjan, Côte d'Ivoire.

Abstract

OBJECTIVES:

To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children.

DESIGN:

Retrospective cohort study with cross sectional study of concordance for HIV antibodies.

SETTING:

Hospital, tuberculosis clinic, and maternal and child health centre in Abidjan, Côte d'Ivoire, west Africa.

SUBJECTS:

986 women who had had a total of 2758 pregnancies since 1980. The last born children of 194 of these women.

MAIN OUTCOME MEASURES:

Pregnancy outcomes; mortality for all children born since 1980; and outcome for last born children. Serological concordance between mothers and last born children.

RESULTS:

Women with HIV-1 and HIV-2 infections had higher rates of spontaneous abortion and stillbirth than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2 positive, 31/234 in dually reactive, and 96/1131 in uninfected). Compared with children born to uninfected mothers (mortality 10.3%), greater proportions of children of HIV-1 positive (20.6%) and dually reactive (20.3%) mothers had died; mortality in children of HIV-2 infected women (13.1%) was not significantly increased. Infant mortalities for the last born children of HIV-1 positive, dually reactive, HIV-2 positive, and seronegative women were, respectively, 133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children of HIV-1 positive mothers were concordantly seropositive compared with none of 21 children of HIV-2 infected mothers.

CONCLUSIONS:

Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate.

Comment in

PMID:
8124173
PMCID:
PMC2539507
[Indexed for MEDLINE]
Free PMC Article
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