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Biochim Biophys Acta. 1994 Mar 2;1199(2):224-8.

Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin.

Author information

1
Inflammation Research Group, London Hospital Medical College, University of London, UK.

Abstract

Matrilysin is shown to rapidly inactivate alpha 1PI, an inhibitor of elastase, by cleaving the Pro357-Met358 peptide bond of its reactive centre. The rate of inactivation of alpha 1PI by matrilysin is four times higher than stromelysin. Matrilysin cleaves oxidised alpha 1PI at the Phe352-Leu353 bond, whilst stromelysin cleaves oxidised alpha 1PI at the Met358-Ser359 bond. We conclude that matrilysin is a potent serpinase which could play a role in inflammatory tissue damage by proteolytically inactivating alpha 1PI.

PMID:
8123672
DOI:
10.1016/0304-4165(94)90119-8
[Indexed for MEDLINE]

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