Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1994 Feb 28;199(1):306-12.

Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice.

Author information

1
Department of Pathology, University Hospital, Linköping, Sweden.

Abstract

Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation.

PMID:
8123028
DOI:
10.1006/bbrc.1994.1229
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center