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Trends Genet. 1993 Dec;9(12):413-21.

Site-specific recombinases: tools for genome engineering.

Author information

1
Institute of Biotechnology, University of Cambridge, UK.

Abstract

Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.

PMID:
8122308
DOI:
10.1016/0168-9525(93)90104-p
[Indexed for MEDLINE]

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