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Arch Pediatr Adolesc Med. 1994 Feb;148(2):153-7.

Outbreak of pertussis in a fully immunized adolescent and adult population.

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1
University School of Medicine, Cener for Vaccine Development, St Louis, Mo.

Abstract

OBJECTIVE:

To evaluate the spread of pertussis in a fully immunized eighth-grade class and the household contacts of two coindex cases of pertussis.

DESIGN:

Survey of infected subjects and their contacts was performed using culture, direct fluorescent antibody assay, and serological assays to establish the diagnosis of Bordetella pertussis.

SETTING:

Middle-class parochial school.

PARTICIPANTS:

A volunteer sample of 15 eighth-grade students and 13 household contacts of two identified cases of B pertussis infection.

INTERVENTIONS:

All participants had medical histories (including immunization status) and laboratory evaluation for B pertussis infection (including nasopharyngeal specimens and serum samples) obtained initially and 30 days later. After initial evaluation, all subjects received erythromycin ethyl succinate therapy.

MAIN OUTCOME MEASURES:

Assessment of B pertussis infection as defined by positive nasopharyngeal culture, direct fluorescent antibody, or serological tests.

RESULTS:

Laboratory evidence of B pertussis infection was found in eight (47%) of 17 immunized eighth-grade classmates and in three (23%) of 13 household contacts, all of whom were 12 years of age or older.

CONCLUSIONS:

Vaccine-induced immunity wanes by early adolescence. These older age groups may be infected with B pertussis and may serve as reservoirs of infection for other susceptible individuals.

PMID:
8118532
[Indexed for MEDLINE]
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