Abstract
In a randomised, placebo-controlled, double-blind study with parallel group comparison, the efficacy and tolerability of topical treatment with a mucopolysaccharide polysulphate/salicylic acid cream was investigated in 156 patients with acute sprains of the knee or ankle joint. There was a more rapid reduction in pain on movement (the main parameter) in the active drug group compared with the placebo group. On day 9 after randomisation the difference was highly significant. There were no adverse events in the active drug group.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Administration, Topical
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Adolescent
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Adult
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Aged
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Ankle Injuries / drug therapy*
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Anti-Inflammatory Agents / administration & dosage*
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Double-Blind Method
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Drug Combinations
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Female
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Heparin / administration & dosage*
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Humans
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Hydrocortisone*
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Knee Injuries / drug therapy*
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Male
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Middle Aged
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Ointments
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Salicylates / administration & dosage*
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Sprains and Strains / drug therapy*
Substances
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Anti-Inflammatory Agents
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Drug Combinations
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Ointments
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Salicylates
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movelat
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Heparin
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Hydrocortisone