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Ophthalmology. 1994 Feb;101(2):360-4.

Risk factors in the development of ocular surface epithelial dysplasia.

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1
Department of Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Abstract

BACKGROUND:

Ocular surface epithelial dysplasia involves a spectrum of diseases ranging from only minor eye irritation to blindness and potentially death.

METHODS:

A case-control study involving 60 patients with ocular surface epithelial dysplasia treated between 1972 and 1991 and 60 age- and sex-matched individuals was conducted to compare relative ultraviolet light exposures over their lifetimes. A standardized self-administered ultraviolet exposure questionnaire was used for assessment.

RESULTS:

Risk factors identified include phenotypic features such as fair skin (odds ratio [OR], 5.4; 95% confidence interval [CI], 1.1, 25.6), pale iris (OR, 1.8; 95%; CI, 0.9, 3.8), and propensity to sunburn (OR, 3.8; 95% CI, 0.7, 19.7), history of previous skin cancers removed (OR, 15; 95% CI, 2.0, 113.6), and being outdoors more than 50% of time in the first 6 years of life while living 30 degrees or less from the equator (OR, 7.5; 95% CI, 1.8, 30.6).

CONCLUSION:

These risk factors suggest that ocular surface epithelial dysplasia is an ultraviolet light-related disease.

PMID:
8115157
[Indexed for MEDLINE]
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