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Nature. 1994 Jan 27;367(6461):338-45.

Structure of pentameric human serum amyloid P component.

Author information

1
Laboratory of Molecular Biology, Birkbeck College, London, UK.

Abstract

The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.

PMID:
8114934
DOI:
10.1038/367338a0
[Indexed for MEDLINE]

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