Format

Send to

Choose Destination
J Occup Med. 1993 Dec;35(12):1231-5.

Occupational asthma to the slime mold Dictyostelium discoideum.

Author information

1
Division of Allergy and Immunology, St Louis University School of Medicine, MO 63104-1028.

Abstract

Dictyostelium discoideum is a slime mold that exists in a unicellular amoeboid form under certain nutritional conditions. In this form, it produces unique lysosomal enzymes that are valuable in studying cell-to-cell signaling systems. We report on a research microbiologist who developed rhinoconjunctivitis and asthma after release of D. discoideum from a pressurized canister. Immediate skin test reactivity was demonstrated to whole and lysed organisms. Enzyme-linked immunosorbent assay results revealed IgE antibody against D. discoideum whole organism, lysed organism, and lysosomal enzymes with the strongest response being directed toward lysosomal enzymes. Pulmonary function testing showed a decline in forced expiratory volume in 1 second and forced expiratory flow after modified laboratory exposure to D. discoideum. This case represents the first report of occupational rhinoconjunctivitis and asthma from slime mild.

PMID:
8113927
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center