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J Bacteriol. 1994 Mar;176(5):1530-4.

Identification of a genetic locus involved in the biosynthesis of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B Neisseria meningitidis.

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1
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303.

Abstract

We characterized the genetic defect of a capsule-deficient serogroup B meningococcal strain created by Tn916 mutagenesis. The transposon insertion interrupts a capsule biosynthesis gene, synX, which is involved in the production of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B meningococci.

PMID:
8113198
PMCID:
PMC205225
[Indexed for MEDLINE]
Free PMC Article
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