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FEBS Lett. 1994 Feb 21;339(3):265-8.

YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions.

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Department of Biology, Faculty of Science, University of Tokyo, Japan.

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  • FEBS Lett 1994 Apr 25;343(2):181.


The grpE gene is a heat shock gene of Escherichia coli whose product functions as a chaperone to (re)fold proteins. We found a yeast homologue of grpE and designated it YGE1. YGE1 can replace grpE in E. coli, indicating that YGE1 is a functional homologue of grpE. Deletion of YGE1 is lethal. During depletion of the Yge1 product, mitochondria are sequestered in mother cells thereby accumulating cells without mitochondria, suggesting that Yge1 protein plays a pivotal role in maintaining mitochondrial functions.

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