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Clin Chim Acta. 1993 Nov 15;220(2):157-64.

Quantification of 3-methylglutaconic acid in urine, plasma, and amniotic fluid by isotope-dilution gas chromatography/mass spectrometry.

Author information

1
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Abstract

A method is described for quantification of the trace metabolite, 3-methylglutaconic acid, by isotope-dilution gas chromatography/mass spectrometry using synthetic 3-[2,4,6-13C3]methylglutaconic acid. Results are shown for quantification of 3-methylglutaconic acid in plasma, urine, cerebrospinal fluid and amniotic fluid for both normal controls and patients with different forms of 3-methylglutaconic aciduria. A simple method for the synthesis and purification of 3-[2,4,6-13C3]methylglutaconic acid is also described.

PMID:
8111960
DOI:
10.1016/0009-8981(93)90044-5
[Indexed for MEDLINE]

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