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Clin Neuropharmacol. 1993 Oct;16(5):418-27.

Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys.

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1
Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.

Abstract

A group of four monkeys was rendered parkinsonian with the toxin MPTP. They were then treated chronically with L-DOPA/benserazide 50/12.5 mg/kg given orally daily for 2 months. This dose produced a striking antiparkinsonian effect, but all animals manifested dyskinesia. A series of agents acting primarily on neurotransmitters other than dopamine were then tested in combination with L-DOPA to see if the dyskinetic movements would be modified. Several drugs, including clonidine, physostigmine, methysergide, 5-MDOT, propranolol, and MK-801, markedly reduced the dyskinetic movements but at the cost of a return of parkinsonian symptomatology. However, yohimbine and meperidine reduced predominantly the dyskinetic movements. Baclofen was also useful in one monkey against a more dystonic form of dyskinesia. Atropine converted the dystonic movements into chorea.

[Indexed for MEDLINE]

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