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Immunol Today. 1993 Jun;14(6):281-4.

Adjuvants: current status, clinical perspectives and future prospects.

Erratum in

  • Immunol Today. 2008 Apr;29(4):149.

Abstract

Adjuvants represent a key issue for vaccines currently under development. Adjuvanticity is linked to the ability to stimulate the T-cell subsets that control the major features of specific immune responses: CD4+ TH1 and TH2 cells and CD8+ cells involved in cytotoxic T lymphocyte responses. Some well-defined immunomodulatory compounds can achieve this stimulation by inducing selective production of appropriate cytokines. Fran├žoise Audibert and Luc Lise review the development of adjuvants and discuss how their combination with suitable vehicles should allow customization of adjuvant preparations capable of inducing protective immune responses better adapted to each type of pathogenicity.

PMID:
8104409
DOI:
10.1016/0167-5699(93)90046-N
[Indexed for MEDLINE]

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