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J Nat Prod. 1993 Jul;56(7):1123-9.

A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts.

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Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, MD 21702-1201.


A relatively high percentage (ca. 15%) of aqueous extracts from terrestrial plants, cyanobacteria, and marine invertebrates and algae has exhibited activity in the National Cancer Institute's primary AIDS-antiviral screen. By removal of anionic polysaccharides in a first stage of dereplication, we have eliminated from further consideration a considerable number of these extracts. However, a still substantial proportion of the active extracts remained, from which we wished to select and prioritize a small percentage for our detailed bioassay-directed fractionation studies. Therefore, a chemical screening protocol, utilizing various solid-phase extraction cartridges, has been developed for a second-stage dereplication and to assist in prioritization of these extracts for our further investigations.

[Indexed for MEDLINE]

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