[Monoclonal antibodies to the beta-chain of the LFA-1 molecule promote an increase in the cytotoxic index of effector lymphocytes and stimulate their proliferation]

I A Popov; N G Anosova; A A Bakova; B D Brondz; Iu S Krivoshein; V V Kronin

[Monoclonal antibodies to the beta-chain of the LFA-1 molecule promote an increase in the cytotoxic index of effector lymphocytes and stimulate their proliferation]

Biull Eksp Biol Med. 1993 Jun;115(6):639-40.

[Article in Russian]

Authors

I A Popov, N G Anosova, A A Bakova, B D Brondz, Iu S Krivoshein, V V Kronin

PMID: 8104051

Abstract

The influence of monoclonal antibodies (mAb) to LFA-1 molecule beta-chain on the functional activities of immune splenocyte fractions which were eluted from donor, third party and recipient macrophage monolayers was studied. The splenocyte fractions were treated with the mAb and tested for cytotoxicity and proliferation. MAb to LFA-1 molecule beta-chain (without co-stimulation by other antibodies) were found to stimulate the immune response of the splenocyte fractions in both functional tests. The observed effect might be non-specific. The relationship between the stimulation of proliferative and cytotoxic responses of the immune splenocyte fractions and the treatment with mAb of LFA-I molecule beta-chain remains obscure.

Publication types

Comparative Study

MeSH terms

Animals
Antibodies, Monoclonal / pharmacology*
Antigens, CD / immunology*
CD18 Antigens
Cell Division / drug effects
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic / drug effects*
Cytotoxicity, Immunologic / immunology
Immunization
Lymphocyte Function-Associated Antigen-1 / immunology*
Mice
Mice, Inbred Strains
Spleen / cytology
Spleen / immunology
T-Lymphocytes, Regulatory / drug effects*
T-Lymphocytes, Regulatory / immunology

Substances

Antibodies, Monoclonal
Antigens, CD
CD18 Antigens
Lymphocyte Function-Associated Antigen-1