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Lancet. 1993 Sep 11;342(8872):651-2.

Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.

Author information

1
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.

Abstract

Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.

PMID:
8103148
DOI:
10.1016/0140-6736(93)91761-a
[Indexed for MEDLINE]

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