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Nature. 1993 Aug 26;364(6440):771-6.

Association of folding intermediates of glycoproteins with calnexin during protein maturation.

Author information

1
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.

Abstract

Calnexin, an endoplasmic reticulum transmembrane protein, represents a new type of molecular chaperone that selectively associates in a transient fashion with newly synthesized monomeric glycoproteins in HepG2 cells. Calnexin only recognizes glycoproteins when they are incompletely folded. Dissociation of glycoproteins from calnexin occurs at different rates and is related to the time taken for their folding, which may then initiate their differential transport rates from the endoplasmic reticulum.

PMID:
8102790
DOI:
10.1038/364771a0
[Indexed for MEDLINE]

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