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Lancet. 1993 Aug 28;342(8870):536-9.

Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs.

Author information

1
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Abstract

The pathogenesis of rheumatoid arthritis and the mode of action of anti-rheumatic drugs are unknown. This hypothesis proposes that haemopoietic growth factors (colony stimulating factors [CSFs]) have an important role in rheumatoid arthritis as regulators of myelopoiesis and as activators of inflammatory leucocytes. It also suggests that slow-acting anti-rheumatic drugs may work by inhibiting myelopoiesis. This opposition to one of the actions of the CSFs would result in fewer inflammatory cells in the inflamed joints.

PMID:
8102674
DOI:
10.1016/0140-6736(93)91653-4
[Indexed for MEDLINE]

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