Format

Send to

Choose Destination
Semin Immunol. 1993 Jun;5(3):187-94.

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion.

Author information

1
Department of AIDS and Retroviruses, Institut Pasteur, Paris, France.

Abstract

The gradual depletion of CD4+ T lymphocytes during the development of AIDS may be due, at least in part, to a process referred to as apoptosis. This process involves a Ca2+ dependent nuclear endonuclease that cleaves the chromatin at internucleosomal junctions. In addition, we have recently provided evidence that apoptosis may be responsible not only for the progressive loss of CD4+ T lymphocytes but may be operative in CD8+ T lymphocytes as well. Here, we describe mechanisms which by direct and indirect pathways may induce apoptosis during HIV infection and thus leading to elimination of T cells.

PMID:
8102263
DOI:
10.1006/smim.1993.1022
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center