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Neuroreport. 1993 May;4(5):543-6.

Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum.

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Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.


The impact of cocaine self-administration on the expression of striatal preprodynorphin and c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly increased preprodynorphin mRNA in the dorsal, but not ventral, striatum. Expression of c-fos mRNA in cocaine-administering rats did not differ from that in controls in all structures examined. These results indicate that the expression of preprodynorphin, but not c-fos, is upregulated in rat striatum as a consequence of cocaine self-administration. Furthermore, these data indicate that the regulation of preprodynorphin is dissociable from the expression of c-fos in rats exposed to repeated doses of cocaine.

[Indexed for MEDLINE]

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