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Immunol Today. 1993 Apr;14(4):161-4.

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

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Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.


Before CD4+ T cells are depleted, T cells in asymptomatic HIV-infected individuals are functionally abnormal. These T cells are programmed for death, are non-responsive and fail to produce interleukin-2 after antigenic stimulation. Our view is that these different T-cell abnormalities are explained by the effects of HIV on antigen-presenting cells. Alteration of the functions of the antigen-presenting cell may program T cells for activation-induced death, and may induce anergy in interleukin-2 and interferon-gamma secreting TH1 cells. This results in predominance of TH2 allergic responses instead of cellular immunity dependent on TH1 cells.

[Indexed for MEDLINE]

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