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Philos Trans R Soc Lond B Biol Sci. 1993 Mar 29;339(1289):313-25; discussion 325-6.

Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1.

Author information

1
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.

Abstract

Two families of molecular chaperone, the hsp 60-GroEL family and the TF55-TCP1 family, have been discovered in evolutionarily related cellular compartments. A member of one of these families, hsp 60, has been shown to play a global role in polypeptide chain folding in mitochondria. We review here studies of both hsp 60 and other family members, discussing their essential physiological roles and mechanism of action.

PMID:
8098536
DOI:
10.1098/rstb.1993.0030
[Indexed for MEDLINE]

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