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Trends Genet. 1993 Mar;9(3):75-9.

Transcriptional activation of Drosophila homeotic genes from distant regulatory elements.

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Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.


In Drosophila the genes responsible for specifying segment identity (the homeotic genes) are transcribed in complex patterns during development. Mutations that mimic loss of homeotic gene activity identify cis-acting DNA sequences and trans-acting proteins required for transcriptional activation. Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements.

[Indexed for MEDLINE]

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