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Neurosci Lett. 1993 Feb 19;150(2):129-32.

Effects of calcium chelators on intracellular calcium and excitotoxicity.

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Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.


In an attempt to probe the relationship between excitotoxicity and increases in intracellular calcium ([Ca2+]i), BAPTA-AM and its analogs were applied to cultured hippocampal neurons. Chelation of [Ca2+]i depressed and prolonged transient responses to glutamate and did not effect elevation of [Ca2+]i by prolonged exposure. This explains the inability of the chelators to prevent glutamate-induced toxicity.

[Indexed for MEDLINE]

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